25i-NBOMe

Introduction to 25i-NBOMe

25i-NBOMe, also known as 25i, N-Bomb, or NBOMe series compound, is a synthetic research chemical develope in 2003 at the Free University of Berlin. It belongs to the phenethylamine class and was originally synthesized to aid in mapping serotonin receptors in the brain. Over time, it has become a focus in forensic toxicology and laboratory research due to its structural similarity to LSD and its psychoactive effects in experimental studies.

25i-NBOMe Chemical Identity

25i-NBOMe’s formal name is 2-(4-Iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine. It has a molecular formula of C18H22INO3 and a molecular weight of 427.28 g/mol.
CAS Number: 919797-19-6
Chemical Class: Phenethylamine derivative
Receptor Target: 5-HT2A and 5-HT1A serotonin receptors
Synonyms: 25I-NBOMe, 25I, N-Bomb, Smiles

These identifiers are use in analytical and forensic laboratories to ensure accurate chemical classification and purity testing.

25i-NBOMe Physical and Chemical Properties

25i-NBOMe typically appears as a white to off-white crystalline powder or is distribute on blotter paper for laboratory reference purposes. It demonstrates potent receptor affinity, making it useful in neurochemical mapping and receptor binding studies. The compound is stable under cool, dry conditions and soluble in common organic solvents such as ethanol and methanol, which supports its use in analytical reference solutions.

Research and Laboratory Applications

25i-NBOMe serves as an analytical standard in forensic science and academic research. Laboratories employ this substance to study serotonin receptor interactions and to enhance understanding of novel psychoactive substances (NPS). Researchers use it to evaluate chemical detection methods, confirm identification accuracy through GC/MS reference and LC-MS reference testing, and investigate metabolic behaviors for toxicological profiling.

Toxicology and Safety Overview

As a psychoactive phenethylamine analog, Is known for its high potency and narrow safety margin. Even minute doses can produce strong hallucinogenic effects due to overstimulation of serotonin receptors, particularly 5-HT2A. Research findings emphasize the potential for serotonin syndrome, cardiovascular instability, and neurological overstimulation when misused. For this reason, NBOMe compound is classifie as a Schedule I controlle substance under U.S. law, indicating no accepted medical use and a high risk of adverse outcomes.

Storage and Stability

The compound should be stored at –20°C in an airtight, moisture-free container to preserve its stability for long-term reference use. Under proper storage, its analytical reliability can be maintaine for up to five years. Laboratories transport it at room temperature under controlle shipping regulations, ensuring compliance with forensic analysis and chemical safety standards.

Product Specifications

• Product Type: Analytical reference chemical
• Chemical Class: Phenethylamine derivative
• Color: White to off-white
• Purity: ≥98% (HPLC verified)
• Molecular Formula: C18H22INO3
• Form: Powder or blotter reference sample
• Storage: -20°C, dry and cool
• Usage: Forensic and toxicological research only
• Features: High purity, stable compound, accurate analytical reference

Conclusion

25i-NBOMe remains a significant compound in research chemistry and forensic toxicology, offering insight into the effects of serotonin receptor agonists and the challenges of identifying designer drugs. Although strictly prohibite for human consumption, it serves an essential role as a reference standard in laboratories studying the mechanisms, metabolism, and detection of novel psychoactive substances.

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